Main Street in Hyannis is home to a number of organizations that enrich the community.

Total Businesses: 22

Please choose one of the businesses below for more information.
Click here to view our interactive map

Alliance to Protect Nantucket Sound

Alliance to Protect Nantucket Sound

4 Barnstable Road

Phone:(508) 775-9767

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American Red Cross

American Red Cross

286 South Street

Phone:(508) 775-1540

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American Red Cross

286 South Street

Armed Forces Career Center

540 Main Street

Phone:(508) 771-0420

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Barnstable Police Department

Barnstable Police Department

1200 Phinney's Lane
491 Main Street

Phone:(508) 775-0387

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Barnstable Police Department

1200 Phinney's Lane
491 Main Street

Barnstable Town Hall

Barnstable Town Hall

367 Main Street

Phone:(508) 862-4610

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Barnstable Town Hall

367 Main Street

Barnstable Town Offices

Barnstable Town Offices

200 Main Street

Phone:(508) 862-4610

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Baybridge Club House

Baybridge Club House

278 Main Street

Phone:(508) 778-4234

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Baybridge Club House

278 Main Street

Cape & Islands Veterans Outreach Center

Cape & Islands Veterans Outreach Center

569 Main Street
Suite 6

Phone:(508) 778-1590

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Cape Cod Community College

Cape Cod Community College

540 Main Street

Phone:(508) 375-5000

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Christian Science Reading Room

Christian Science Reading Room

357 Main Street

Phone:(508) 775-0874

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Department of Developmental Services

181 North Street #4

Phone:(508) 771-2595

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Department of Mental Health

181 North Street

Phone:(508) 957-0900

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Department of Transitional Assistance

181 North Street

Phone:(508) 862-6600

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Hyannis Post Office

Hyannis Post Office

385 Main Street

Phone:(508) 775-7344

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Hyannis Post Office

385 Main Street

Hyannis Public Library

Hyannis Public Library

401 Main Street

Phone:(508) 775-2280

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Hyannis Public Library

401 Main Street

Hyannis Youth & Community Center

Hyannis Youth & Community Center

141 Basset Lane

Phone:(508) 790-6345

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Jewish Federation of Cape Cod

Jewish Federation of Cape Cod

396 Main Street

Phone:(508) 775-5588

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Massachusetts Rehabilitation Commission

181 North Street

Phone:(508) 775-6173

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Odd Fellows Cape Cod Lodge

354 Main Street

Phone:(508) 775-2687

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Pope John Paul II High School

Pope John Paul II High School

120 High School Road

Phone:(508) 862-6336

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Pope John Paul II High School

120 High School Road

Sturgis Public Charter School

Sturgis Public Charter School

427 Main Street

Phone:(508) 778-1782

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Visitor's Information Center

Visitor's Information Center

397 Main Street

Phone:(508) 775-2201

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Our Mission

To promote the community and economic development of the Main Street, Hyannis district as a desirable place to live, work, invest, and visit.

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Hyannis Main Street Business Improvement District
397 Main Street, P.O. Box 547, Hyannis, MA 02601

Phone (508) 775-7982

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